> See also: > - Reference # Cytokines and Mental Health ## Preface - Psychoneuroimmunology: ## Chapter 12 - Cytokine Regulation in Major Depression - Depression is a form of stress → Stress has been associated with immune dysregulation (particularly immune suppression) - Depression is associated with hyperactivity of the hypothalamic-pitituary adrenal (HPA) axis resulting in an increased secretion of cortisol (an immunosuppressive hormone)