> See also: > - [[Recombinant DNA Technology]] # CRISPR **CRISPR** stands for *clustered regularly interspaced short palindromic repeats* This system essentially acts as the [[Adaptive Immunity|adaptive immune system]] of bacterial cells. Spacers ![[CRISPR.png]] [External URL](https://www.youtube.com/watch?v=IiPL5HgPehs) [[CRISPR|Internal Note]] ## How Does CRISPR Work? A **ribonucleoprotein (RNP)** is formed when a protein attaches to a nucleic acid chain. ## Post-Cut Behavior > See also: > - DNA Repair and Recombination https://www.youtube.com/watch?v=cLMo6DYdJRE&list=WL&index=4 Once the endonuclease site of the Cas9 protein cleaves the target DNA, two blunt ends will remain. There are special proteins [[Chromosomes|Homologous chromosomes]] share the same structural features such as size, banding pattern (gene locations) ### Nonhomologous End Joining (NHEJ) - ### Homolgy-Directed Repair (HDR) Homology-directed repair