> See also: > - [[Cytokines]] # Chemokines The process of cells being directed through the differing concentration of chemokines is called **chemotaxis** (get it, because they *taxi* the cells around) There are four major classes of chemokines: - CXC - CC - CX3C - C Generally, if a name includes an 'L' (standing for ligand) it will be a chemokine - Ex: CCL2 If a name includes an 'R' it will likely be a receptor - Ex: CCR2 ## CC Family The **CC family** of chemokines generally **induce migration of lymphocytes and monocytes** **CCL2** (MCP-1) - Promotes [[Helper T-Cells|Th2]] immunity and release of histamine by basophils - [ ] Secreted by macrophages activated by the presence of infection which attracts monocytes from the blood into infected tissuend X‑Gal that produces blue colonies an LB agar plate w **CCL3** (MIP-1$\alpha$) - Recruits monocytes/macrophages/neutrophils - Promotes [[Helper T-Cells|Th1]] immunity **CCL4** (MIP-1$\beta$) - Recruits monocytes and natural killer cells **CCL5** (RANTES) - Recruits eosinophils, [[T-Cells]], and basophils - Can activate NK cells **CCL19** - Secreted by stromal cells and dendritic cells in secondary lymphoid tissues - Attracts [[Blood Cells|leukocytes]] and [[dendritic cells]] to the tissue **CCL21** - Attract B-Cells to the T-Cell area of [[Lymph Nodes|lymph nodes]] - *Receptor:* CCR7 ## CXC Family The **CXC family** of chemokines **induce migration of neutrophils** **CXCL8** (IL-8) - Recruits neutrophils to infected tissues **CXCL7** () - Released from activated platelets - Activates neutrophils - Promotes angiogenesis **CXCL1/CXCL2/CXCL3** - Similar to CXCL7 - Promote angiogenesis **CXCL13** - Secreted by [[Dendritic Cells|FDCs]] to guide B-Cells to [[Lymph Nodes|lymph node]] follicles (usually after they had followed CCL21/CCL19)