> See also: > - Reference # DNA & Protein Interactions ![[Pasted image 20240210142734.png|250]] - Zinc finger - helix turn helix - leucine zipper Important Properties of DNA’s Structure - Major vs Minor Groove - Available electrostatic interactions (unique on a nucleotide basis) ## G Proteins guanine nucleotide-binding proteins act as molecular switches ### DNA Binding Proteins **DNA Binding proteins** are a type of *trans-acting* regulation that uses **motifs** to attach onto *cis-acting* **DNA elements** within the target strand Motifs are unique structures within a [[Proteins|protein's]] functional domain that allow them to fit into the major groove of DNA and form hydrogen bonds with both the nitrogen bases and the sugar backbone of the DNA strand. - Zinc Fingers - Leucine Zipper - RNA on RNA violence ![[DNA Binding Protein Examples.png]]