> See also: > - [[Intermolecular Forces]] # DNA Hybridization DNA Hybridization is *NOT a covalent process* DNA bases will only pair in very specific ways (complement pairs). While short sequences won't tolerate mismatches, longer strands are much more susceptible to some mispairings. DNA can be hybridized with ssDNA containing *radiolabeled or fluorescent probes* and become incorporated into the original strand. - This allows it to be analyzed in later techniques such as dot ### Dot Blots > Analogous to an [[Antibody-Based Lab Techniques|ELISA]] or other antibody-based lab techniques which excel at detecting specific targets (proteins/antigens), except rather than antibodies DNA probes are used instead. Dot blots are useful for detecting the presence of target genetic sequences - Because each sample is isolated, it isn't as effective at directly comparing the ### RNase Protection Assay The RNase protection assay allows for the ### DNA Microarrays ![[DNA Hybridization.png|300]]