![[Pasted image 20250319041216.png|425]] # Profile Hidden Markov Models **Profile Hidden Markov Models** are one approach to overcoming the “only influences by preceding state” limitations of first-order markov processes. One extremely important change that must occur for these types of models is the introduction of “regularization” ![[image_3.png|500]] https://www.ebi.ac.uk/training/online/courses/pfam-creating-protein-families/what-are-profile-hidden-markov-models-hmms/